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Analytical servicePeptide Purity & Characterization
Chromatographic characterization establishes what a sample contains: the distribution of its principal component, the related impurities that accompany it and the degree of analytical heterogeneity across the separation. Purity is reported as the method defines it — a chromatographic purity under stated conditions, which is not equivalent to absolute peptide content.
Illustrative figure — the shape of the measurement, not a result.
Chromatographic profiles, impurity assessment, purity estimates and identity-related findings.
Methodology classes
- Reversed-phase liquid chromatography with ultraviolet and diode-array detection
- Alternative separation mechanisms where the question requires orthogonal selectivity
- Gradient and method-specific profiling tuned to the sample's retention behaviour
- Orthogonal detection strategies for impurity assignment
Applicable sample categories
- Synthetic and recombinant peptides
- Peptide conjugates and selected chemical modifications
- Raw materials, intermediates and finished preparations
- Comparative sample sets
Measurable parameters
- Chromatographic purity (area %) under stated conditions
- Impurity distribution and relative abundance
- Retention behaviour and peak characteristics
- Chemical heterogeneity across the profile
Reporting outputs
- Annotated chromatographic profiles
- Impurity assessment with method reference
- Purity estimate qualified to the method and conditions
- Identity-related findings where supported
Fees for this service
Fees are per sample in pounds sterling, excluding VAT, and apply to the methods and scope described on the corresponding service page. Where no fee is listed, the investigation is scoped and quoted after a pre-submission enquiry. Multi-sample series and recurring programmes are priced on request.
| Chromatographic purity & identity | Fee |
|---|---|
| Chromatographic purity, identity and content — single peptideRP-HPLC purity (area %), identity against reference, content per vial | £586 per sample |
| Purity, identity and content with mass-spectrometric identityadds intact mass against the theoretical value | £605 per sample |
| Multi-component preparation — two actives | £389 per sample |
| Multi-component preparation — three or four actives | £848 per sample |
| Blind identity — unknown peptide screenchromatographic profile and intact mass against a reference library | £445 per sample |
| Conformity vial — same lot, same testswith a parent sample | £206 per vial |
| Net peptide content & composition | Fee |
|---|---|
| Amino acid analysis — composition and net peptide content | £374 per sample |
| Elemental net peptide content | £258 per sample |
| Water content / counter-ion content | Request a quotation |
| Injectable safety | Fee |
|---|---|
| Bacterial endotoxin — pass/fail against the stated limitfinished preparations | £285 per sample |
| Sterility — 14-day incubation | £374 per sample |
| Bioburden — total aerobic microbial and yeast/mould counts | £262 per sample |
| Heavy metals — Pb, Cd, As, Hg | £356 per sample |
| Residual solvents | £262 per sample |
| Reconstitution-water panel — endotoxin, benzyl alcohol content, pH | £356 per sample |
| Injectable safety panel — purity, identity, content, endotoxin, heavy metals, bioburden | £695 per sample |
| Full panel — adds sterility and mass-spectrometric identity | £994 per sample |
Describe the sample and the question.
A pre-submission enquiry establishes analytical suitability, experimental requirements, sample handling and reporting expectations before any material is sent.